Anti-Mullerian hormone attenuates both cyclophosphamide-induced damage and PI3K signalling activation, while rapamycin attenuates only PI3K signalling activation, in human ovarian cortex in vitro.

Hum Reprod · 2024 · PMC10833070 · PMID 38070496

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Lastly, regarding the study of chemoprotectants, recent evidence suggests there may be significant value in investigating protective agents in combination, with data showing that co-treatment of temsirolimus and AMH completely prevented cyclophosphamide-induced primordial follicle loss ( Kashi et al. , 2023 ).

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