Acupuncture in circadian rhythm sleep-wake disorders and its potential neurochemical mechanisms.

It has also been demonstrated that acupuncture can drastically lower the expression of the Bmal1, Clock, and Per2 and their pertaining proteins in the cardiomuscular tissue of spontaneous hypertensive rats, as well as a decreasing trend in the levels of Bmal1 and Clock genes in cartilage tissue ( Shu et al., 2021 ; Tan et al., 2022 ). 8 Acupuncture modulation of the central biological clock and pertaining genes The biological clock controls the body’s circadian rhythm oscillation system, which consists of the central biological clock and the peripheral biological clock.

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