Detection methods and dynamic characteristics of specific antibodies in patients with COVID-19: A review of the early literature.

The positive rate of IgM antibody showed a decreasing trend after the 4th week of onset, but the positive rate of IgG antibody did not decrease during two-month's observational period ( Fig. 1 ) [ [43] , [44] , [45] ].In general, the specific IgG antibody production after the pathogen infects the body is later than IgM antibody [ 34 , 35 , 37 , 38 ].Multiple studies have shown that the median time of seropositive conversion of specific IgG antibody in confirmed cases of novel coronavirus infection is 12–14 d after onset [ 46 , 47 ], almost simultaneously with the production of specific IgM antibody.

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