Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy.

For differences between the two groups, ∗∗ P < 0.01 was considered significant while ∗∗∗ P < 0.001 was considered highly significant. 3 Results and discussion 3.1 The design of a dual-responsive logic system We packaged CRISPR plasmid and GOx in acid-degraded amorphous zeolitic imidazolate frameworks-8 (CG@ZIF-8) with a diameter of 50 nm according to the previous description with slight modification 20 ( Fig. 1 A and B).

also in 132,142 other papers