highly significantp = 0.00013
The enrichment of these MCTS1 pLOF variants in our male MSMD cohort without genetic diagnosis ( n = 422, 5 pLOF variants) relative to a cohort comprising both male patients without mycobacterial infections and healthy male individuals ( n = 1,932, 0 pLOF variants) was highly significant ( p = 0.00013).