Associations between Alzheimer's disease biomarkers and postoperative delirium or cognitive dysfunction: A meta-analysis and trial sequential analysis of prospective clinical trials.

In a previous study, the pathogenic peptide Aβ42 level, which is more prevalent in the CSF of Alzheimer's disease patients, showed a decreasing trend. 43 Our meta-analysis confirmed this negative correlation between preoperative CSF Aβ42 levels and POD based on five studies. 21 , 31 – 34 Despite the TSA not reaching the required sample size, the Z -curve crossed the TSMB, indicating that this correlation has reached statistical significance.

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