Moreover, the rs460089 is in highly significant linkage disequilibrium with 7 other regulatory SNPs located in introns of SLC22A4 ( n = 3) and SLC22A5 (OCTN2) ( n = 3), as well as in one locus located downstream of the SLC22A4 .
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The SNP rs460089 in the gene promoter of the drug transporter OCTN1 has prognostic value for treatment-free remission in chronic myeloid leukemia patients treated with imatinib.
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