Combinatorial immune checkpoint blockade increases myocardial expression of NLRP-3 and secretion of H-FABP, NT-Pro-BNP, interleukin-1β and interleukin-6: biochemical implications in cardio-immuno-oncology.

Analyses of protein expression through ELISA method in hPBMC –cardiomyocyte models exhibited highly significant increases in NLRP-3 induced by Atezolizumab, Ipilimumab, Nivolumab and Relatlimab in monotherapy compared to untreated HFC and untreated HFC-hPBMC co-cultures ( Figure 7 ).

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