In the case of plasma TNF-α expression, an increasing trend was observed at 4 weeks in the MCT group, although statistical significance was apparent after 12 experimental weeks of MCT (*P < 0.05).
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The siRNA-mediated knockdown of AP-1 restores the function of the pulmonary artery and the right ventricle by reducing perivascular and interstitial fibrosis and key molecular players in cardiopulmonary disease.
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