Histamine H<sub>2</sub>-receptor antagonism improves conduit artery endothelial function and reduces plasma aldosterone level without lowering arterial blood pressure in angiotensin II-hypertensive mice.

AngII-infusion significantly but transiently decreased heart rate in ranitidine+AngII ( P =0.02 vs baseline)—this was borderline significant in AngII-vehicle-treated animals with P =0.056 vs baseline (Fig. 2 C, D).

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Perspectives Histamine and H 2 receptors may be significant contributors to aldosterone synthesis and release under normal and pathophysiological conditions with elevated circulating levels of angiotensin II.

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