Acute graft versus host disease 1976-2020: reduced incidence and predictive factors.

Front Med (Lausanne) · 2023 · PMC10847269 · PMID 38327272

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

borderline significantp = 0.06so close (0.05 < p ≤ 0.1)

The other major change in prophylaxis has been the addition of PTCY ( 11 , 12 , 16 ) but only for patients receiving a haploidentical transplant: It is rather surprising that, despite mismatched family grafts have a higher risk of GvHD grades II–IV and III–IV, PTCY shows a borderline significant protective effect of 0.71 ( p = 0.06).

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highly significantno p-value reported

Thus, when looking at patients with grade II GvHD in a multivariate analysis, including patients’ age and donor type as covariates, the year of the transplant was a highly significant predictor of TRM, with a relative risk of 0.62 and 0.35 for the year 2000–2010 and 2011–2020, compared to patients grafted before year 2000.

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