Understanding the Influence of API Conformations on Amorphous Dispersion Formation Potential Predictions using the <i>R</i>3<i>m</i> Molecular Descriptor.

2 All R 3 m values associated with API that were observed to disperse in PVPVA were assigned a probability of 1 and all API that did not disperse were assigned probability of 0, and the model remained highly significant having p < 0.0001, a pseudo R 2 = 0.91, and χ 2 = 1.52 × 10 4 .

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