Mitochondrial function in peripheral blood cells across the human lifespan.

After adjusting for sex and health status, age-dependent changes remained highly significant in the N/NS pathway control ratio (slope = −0.0007, SD ± 0.0002, P = 0.0002) and the S/NS pathway control ratio for PBMCs (slope = 0.0010, SD ± 0.0002, P = < 0.0001) (Fig. 2 , Supplementary Table 5 ).

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