In contrast to granulocytes, there was no consistent effect of hyperoxia across multiple analyzes in PBMCs, except for a slight trend in the utilization of lipid synthesis indicated by the NADPH-providing oxidative PPP and the acetyl-CoA loss.
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<sup>13</sup>C-Metabolic flux analysis detected a hyperoxemia-induced reduction of tricarboxylic acid cycle metabolism in granulocytes during two models of porcine acute subdural hematoma and hemorrhagic shock.
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