highly significantp ≤ 0.005
E–R relationships for SARS‐CoV‐2 viral load change from baseline at days 5 and 10, slope of viral load decline, and error rate (a direct measure of mechanism of action) were all highly significant ( p ≤ 0.005) for both evidence of drug effect and exposure dependency. 18 E–R results support a consistent interpretation of dose and exposure dependency for molnupiravir across clinical outcome and pharmacodynamic markers, with exposures at 800 mg falling near the top of the E–R curves.