Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases.

9 In our previous pilot study in a high T1D risk cohort, we observed a decreasing trend of PC/PE ratio with high PFAS exposure, 23 indicating changes in the milk fat globule (MFG) size as these polar lipids are mainly located on the structured membrane and with the PC/PE ratio reflecting the size of the MFGs, with a high PC/PE ratio favoring small MFGs. 53 In the current study, we observed the opposite trend in the control group, with a similar but not significant trend in the case group.

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