Imeglimin Exhibits Novel Anti-Inflammatory Effects on High-Glucose-Stimulated Mouse Microglia through ULK1-Mediated Suppression of the TXNIP-NLRP3 Axis.

Moreover, we observed that imeglimin treatment significantly reduced the levels of TXNIP and NLRP3 and almost significantly reduced ASC levels, whereas the ratio of cleaved caspase-1/pro-caspase-1 was not significantly affected by imeglimin under HG conditions ( Figure 3 A–E).

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