Accordingly, in the absence of ligand, ACVR2B did not induce the dissociation of the homodimeric complexes of ALK2-WT ( Figure 5 B); rather, it caused highly significant homodimerization of the mainly monomeric ALK2-R206H ( Figure 6 B; 45% homodimerization).
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The Activation of the Fibrodysplasia Ossificans Progressiva-Inducing ALK2-R206H Mutant Depends on the Distinct Homo-Oligomerization Patterns of ACVR2B and ACVR2A.
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