Sodium Channel β Subunits-An Additional Element in Animal Tetrodotoxin Resistance?

In contrast, a highly significant signature common to all TTX-resistant species was observed in SCN2B at position 35 of the alignment ( Figure 3 , Table 2 ), where the proline found in most TTX-sensitive taxa is replaced by a valine in T. elegans and T. sirtalis and a serine in T. rubripes (asparagine is found in the same position in the TTX-sensitive E. electricus ).

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electricus , although possibly significant in structural terms due to the unique properties of proline vs. alanine [ 46 ], is highly unlikely to confer TTX resistance because current evidence points to VGSCs in this species being TTX-sensitive.

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