Matrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions.

Upon analyzing the overlap between differential ATAC-seq and differential MyoD binding, we observed a total overlap of 253 differential peaks, which represents a highly significant portion of total differential ATAC-seq and MyoD peaks ( P = 2e-15) (Fig. 3g ), suggesting that Matr3 depletion simultaneously perturbs open chromatin regions and MyoD binding.

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