Association of liver fibrosis with extrahepatic cancer in steatotic liver disease patients with PNPLA3 I148M GG genotype.

5.9%, p = 0.001), a marginally significant increase in the rate of the MTHFR C677T Ala222Val‐rs1801133 TT genotype, a marginally significant decrease in the rate of the MTHFR C677T Ala222Val‐s1801133 CC genotype, and a marginally significant increase in the rate of the ALDH2 Glu504Lys‐rs671 GG genotype (Table 2 ). 3.3 Outcomes of patients with and without SLD Of 580 controls, 152 (26.2%) had cardiovascular events; 27 (4.7%) had extrahepatic cancers, including lung ( n = 14, 2.4%) and genitourinary tract cancers ( n = 13, 2.2%), 2 (0.34%) had liver cirrhosis, and none developed HCC.

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