<i>Tlr4</i> Deletion Modulates Cytokine and Extracellular Matrix Expression in Chronic Spinal Cord Injury, Leading to Improved Secondary Damage and Functional Recovery.

The BMS analysis, which evaluates various aspects of hindlimb movement, foot placement, weight-bearing, balance, trunk stability, and coordination in freely moving mice using a 9-point scale ( Basso et al., 2006 ), showed a small but significant improvement in locomotor recovery in the TLR4 KO group at 8 weeks post-SCI as compared with wild-type SCI controls ( Fig. 9 C ; two-way RM-ANOVA; time × genotype effect, F (12,324) = 2.03; p = 0.02; with post hoc Bonferroni’s multiple-comparisons test; p (56) = 0.016; n = 14–15 mice per group).

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