We found that in PBS-treated APP/PS1 mice, the young group showed significantly diminished frequencies of Tregs relative to their wild-type littermates ( Figure 5 ), but an increasing trend with age was observed.
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Treatment with glatiramer acetate in APPswe/PS1dE9 mice at an early stage of Alzheimer's disease prior to amyloid-beta deposition delays the disease's pathological development and ameliorates cognitive decline.
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