The Mediating Effect of the Choline-to-Betaine Ratio on the Association Between <i>PEMT</i> rs7946 and Digestive System Cancer: A Nested Case-Control Study in a Chinese Population.

However, compared with matched controls, the cases were more likely to have higher serum betaine concentrations, although this difference was just above the margin of significance ( P = 0.054) and had a significantly lower value of choline-to-betaine ratio ( P = 0.033).

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Association between PEMT rs7946 and risk of incident cancer As shown in Table 2 , after adjusting for potential confounders, CT and CC carriers conferred an increasing trend for digestive system cancer risk compared with participants with the TT genotype.

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