While there was a slight trend towards a higher percentage of alive (YFP+) spores per larvae in rac2 −/− versus rac2 +/+ larvae, this difference was not statistically significant, suggesting that Rac2 is not required for spore killing ( Fig. 3C ).
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Macrophages inhibit extracellular hyphal growth of <i>A. fumigatus</i> through Rac2 GTPase signaling.
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