Higher Cumulative Blood Pressure in Midlife Predicts an Increased Risk of Atrial Fibrillation: Evidence From the Atherosclerosis Risk in Communities Study.

For instance, the Women's Health Study, which enrolled 34 221 women, demonstrated a highly significant increase in the risk of incident AF across increasing categories of SBP and DBP, although SBP outweighed DBP. 30 Another study using data from the ARIC cohort showed that DBP was associated with a lower risk of AF (HR, 0.90 [95% CI, 0.84–0.97]). 21 However, the Framingham Heart Study did not observe a significant association between DBP and AF risk. 29 Further studies are needed to elucidate this controversy and shed light on the underlying mechanisms.

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