<i>In vitro</i> and <i>in vivo</i> models define a molecular signature reference for human embryonic notochordal cells.

Indeed, SB431542 treatment reduced off-target differentiation such as cardiac derivatives (highly significant downregulation of key cardiac markers HAND1 and PRRX1 ) as well as endoderm derivatives (significant downregulation of GATA4 and a trend to a downregulation of SOX17 expression) and in contrast promoted NLC differentiation as demonstrated by the significant increase expression of NOTO and TBXT markers ( Figure 2 E).

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