Sex-dependent placental methylation quantitative trait loci provide insight into the prenatal origins of childhood onset traits and conditions.

11 An alternative approach would have been controlling for local ancestry using linear mixed-effect models, which in previously reported simulations provided a small but significant reduction in the false positive rate in instances where simulated eQTL were ancestry-specific. 77 Using this model to detect sex-specific effects would require new methodology, which was beyond the scope of our study.

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