Further, the study showed an increasing trend of extended-spectrum β-lactamase (ESBL)-producing E. coli isolates over recent years, with relative average yearly increases of 7.7% (95% confidence interval [CI], 7.2–8.2%; p < 0.0001) [ 12 ].
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Prevalence, regional distribution, and trends of antimicrobial resistance among female outpatients with urine Klebsiella spp. isolates: a multicenter evaluation in the United States between 2011 and 2019.
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