Infrapatellar fat pad adipose tissue-derived macrophages display a predominant CD11c+CD206+ phenotype and express genotypes attributable to key features of OA pathogenesis.

We selected eight pathways from each database that reflected macrophage function and may be related to OA pathogenesis with the most highly significant p-values (p<0.05) from each database..

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However, the expression of IL-1β, TNF-α, and IL-6, respectively, in CD11c-CD206+ and CD11c+CD206+ macrophages were above the negative background level and showed an increasing trend, with CD11c+CD206+ expressing these cytokines at the highest levels, followed by CD11c-CD206+ macrophages ( Supplementary Figure S5 ).

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