Highly Accurate Estimation of Cell Type Abundance in Bulk Tissues Based on Single-Cell Reference and Domain Adaptive Matching.

Although cell type decomposition on bulk RNA‐seq data using scRNA‐seq references is an appealing analysis strategy, it is important to note that there may be significant differences in data distribution between scRNA‐seq and bulk RNA‐seq data, and unreliable feature matrices generated from single‐cell references can lead to the identification of incorrect cell types.

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