Radiation Therapy for Colorectal Liver Metastasis: The Effect of Radiation Therapy Dose and Chemotherapy on Local Control and Survival.

On multivariate analysis (MVA), the association remained statistically significant for lines of chemotherapy (HR, 2.58; 95% CI, 1.42-4.66; P = .002) and lesion size (HR, 1.94; 95% CI, 1.04-3.60; P = .037), whereas borderline significance was observed for BED10 (HR, 1.83; 95% CI, 0.98-3.42; P = .057; Table 2 ).

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BED10 below 96 Gy and receipt of ≥3 lines of chemotherapy were associated with worse FFLP (hazard ratio [HR], 2.69; 95% CI, 1.54-4.68; P < .001 and HR, 2.67; 95% CI, 1.50-4.74; P < .001, respectively) and OS (HR, 2.35; 95% CI, 1.35-4.09; P = .002 and HR, 4.70; 95% CI, 2.37-9.31; P < .001) on univariate analyses, which remained significant or marginally significant on multivariate analyses.

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