LARP4 is an RNA-binding protein that binds nuclear-encoded mitochondrial mRNAs to promote mitochondrial function.

By setting a cutoff for mitochondrial enrichment at a log 2 (fold-change) > 0.5, we observed a highly significant overlap of LARP4 targets in the puromycin condition indicating many of the mRNAs which localize to mitochondria via RNA-dependent modes are also LARP4 targets ( Fig. 1 I).

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