The vagus nerve mediates the physiological but not pharmacological effects of PYY<sub>3-36</sub> on food intake.

However, meals were significantly smaller and shorter in NG Y2R KD compared with controls ( Figure 2 , Figure 3 ); probability density functions for meal patterning readouts further illustrate highly significant differences (p < 0.0001) in average meal size and duration ( Suppl Figs. 3f and 3g ), with a trend to shorter intermeal durations, particularly in the dark phase ( Figure 3 ).

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