Reversal of Pulmonary Hypertension in a Human-Like Model: Therapeutic Targeting of Endothelial DHFR.

The tg-EC-DHFR mice were also protected from developing elevated RVSP (Figure 4 B; P =0.050 for the DAHP model and P =0.088 for the hypoxia model with marginal significance), as well as increased RV/(LV+S) ratio (Figure 4 C; P =0.047 for the DAHP model and P =0.006 for the hypoxia model), in response to either DAHP administration or hypoxia exposure.

also in 5,069 other papers