Tumor histoculture captures the dynamic interactions between tumor and immune components in response to anti-PD1 in head and neck cancer.

2A ), along with a highly significant increase in IFNg secretion and up-regulation of IFNg pathway genes (Fig. 2 A, E ) alleviates the need for a functional circulatory system for demonstrating response.

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On treatment SC1 samples exhibited an increasing trend in M1/M2 GES that correlated with a near significant increase in GMCSF:MCSF ratio compared to SC2d (Fig. 5A ).

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Using a mIHC approach, Treg numbers were found to have a decreasing trend on combination treatment (Fig. 8C , left).

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