Association of sex and aspirin use with postoperative bleeding in patients with lower extremity long bone fractures.

Women were found to have a 0.55 g/dL greater decrease in hemoglobin than men that was borderline significant, p=0.07. 26 Hang et al , studied the effect of perioperative administration of aspirin for patients undergoing total knee arthroplasty and reported that continued aspirin therapy did not affect blood loss, and female sex was also not a risk factor for blood loss in their population. 27 In the setting of CVD, there have been numerous studies examining sex-specific differences in bleeding outcomes with aspirin and other antiplatelet agents.

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