TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome.

Likewise, the A3’SS and A5’SS events exhibit a slight trend towards inclusion, consistent with the high frequency of RIs (Fig. 3B ).

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No statistical difference in the (N/C) poly A + fluorescent intensity ratio was identified between THOC6 affected and unaffected control hNPCs, while a highly significant increase in the N/C poly A + signal intensity ratio was measured in THOC6 +/+ hNPCs treated with WGA attributed to high accumulation of poly A + RNA in the nucleus (Fig.

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