Establishment of a Human Immunocompetent 3D Tissue Model to Enable the Long-Term Examination of Biofilm-Tissue Interactions.

In the co-cultured M1 macrophage models ( Figure 6 B), IL4 expression followed an increasing trend when without bacteria and demonstrated a significant increase at day 3 in the models that were exposed to the bacterial film when compared with the models at the experimental start without bacteria.

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M1 is slightly increased compared with the medium without bacteria with a mean value of 1.0, and it is therefore only barely significant.

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p -values < 0.05 were considered to be significant, with p < 0.01 being highly significant.

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