Cell States and Interactions of CD8 T Cells and Disease-Enriched Microglia in Human Brains with Alzheimer's Disease.

We also found no significant difference in CD8 T cell proportions relative to APOE4 carrier status in cases with dementia, but we found a positive trend in APOE4 carriers without dementia that was not statistically significant (dementia: log2FC = 0.07, p -value = 0.69, n = 16 APOE4 carriers and 26 APOE4 non-carriers; cognitively normal: log2FC = 0.74, p -value = 0.07, n = 9 APOE4 carriers and 33 APOE4 non-carriers, Wilcoxon rank-sum test).

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