CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation.

In agreement with the concept that the archaeal/bacterial C5 pathway of δALA biosynthesis is not conserved in mammals because an ortholog of the glutamyl-tRNA reductase HemA does not exist, there was only a statistical trend for a 20% increase for the GltX ortholog EARS2, a mitochondrial glutamyl-tRNA synthase, in the CLPP-null mouse brain (see Table S3 in [ 47 ]).

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