Multicenter and Genome-Wide Association Studies (GWAS) Genome-wide association studies (GWAS), as well as a number of large multicenter studies, have significantly expanded knowledge about the genetic basis of T1DM; they have identified about 70 highly significant risk single nucleotide polymorphisms (SNPs) that are not localized in HLA genes.
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Genetic and Epigenetic Aspects of Type 1 Diabetes Mellitus: Modern View on the Problem.
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