Circadian Rhythm Alteration of the Core Clock Genes and the Lipid Metabolism Genes Induced by High-Fat Diet (HFD) in the Liver Tissue of the Chinese Soft-Shelled Turtle (<i>Trionyx sinensis</i>).

In addition, compared with the CON group, the Pparα mRNA levels showed firstly a rising trend, then a downward trend, and lastly an increasing trend in the HFD group.

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In addition, highly significant variations were observed for the mesors and amplitudes of 10 genes ( Clock , Bmal 2, Cry 2, Per 1/2, Nfil 3, Bhlhe 40, Nr 1 d 2 and Rorα / β ) between the liver tissues of the CON group and the HFD group.

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In the present study, we also explored the idea that Pparα mRNA expression had a decreasing trend from ZT 12 h to ZT 21 h; both Clock and Cry 2 mRNA expression in the HFD group presented remarkably lower than that in the CON group at 24 h.

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