Serotonergic and Adrenergic Neuroreceptor Manipulation Ameliorates Core Symptoms of ADHD through Modulating Dopaminergic Receptors in Spontaneously Hypertensive Rats.

SHRs (ADHD model) who received either MDL (5-HT2A antagonist) or IPS (5-HT1A agonist) or GFC (alpha-2 adrenergic agonist) showed a highly significant ( p < 0.001) decrease in these study parameters (mean distance traveled, mean movement velocity) when compared to the SHR-NC group ( Figure 1 A,B).

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