Accounting for isoform expression increases power to identify genetic regulation of gene expression.

If we require the opposite-sign isoform associations to be marginally significant at p < 0.05, then 47.9% (663 of 1383) of the F-test-exclusive eGenes have significant opposite-sign associations, while only 22.1% (144 of 651) of eGenes found by both methods fit this criterion.

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