Repurposed Drugs That Activate Autophagy in Filarial Worms Act as Effective Macrofilaricides.

In addition, similarly to the outcomes we observed in vitro, both treatments significantly affected Wolbachia loads ( p < 0.001, Figure 4 A), reduced the secretion of microfilariae by 36% (Niclosamide; almost significantly, p = 0.065) and by 48% (NEN; p < 0.01, Figure 4 B), as well as significantly reduced the total content of the embryonic stages within the gonads ( p < 0.05 and p < 0.01, respectively) ( Figure 4 C).

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