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COVID-19 Distribution in Pregnancy, Drug Use Patterns and COVID-19 Medication during the Pandemic in Spain: Data from Real-World Electronic Health Records.

Pharmaceuticals (Basel) · 2024 · PMC10892820 · PMID 38399422

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a decreasing trendno p-value reported
Finally, the use of hydroxychloroquine was more frequent by the first and second waves, and then there was a decreasing trend as the waves advanced.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.