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Outcome measures in asthma attack trials: can't see the good for the wheeze.

ERJ Open Res · 2024 · PMC10895438 · PMID 38410716

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an increasing trendno p-value reported
[ 10 ] found an increasing trend over time towards larger, adequately powered studies with defined primary outcomes, and greater inclusion of healthcare utilisation and patient-reported outcomes.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.