Combining In Vitro and In Silico New Approach Methods to Investigate Type 3 Iodothyronine Deiodinase Chemical Inhibition Across Species.

Of the possible 21 pairwise IC50 comparisons, XTH has 15 variant pair differences that are highly significant ( p ≤ 0.001), two pairs that are significantly different at p ≤ 0.05, and four pairs that are not significantly different ( p > 0.05; Figure 2 ; Supporting Information , Table S3 ).

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