Barely Significant
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Add-on Sacubitril/Valsartan Therapy Induces Left Ventricular Remodeling in Non-responders to Cardiac Resynchronization Therapy to a Similar Extent as in Heart Failure Patients Without Resynchronization.

Cardiol Ther · 2024 · PMC10899553 · PMID 38216822

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highly significantno p-value reported
The introduction of sacubitril/valsartan (SV), a new therapeutic class of agents acting on the renin–angiotensin system (RAS) and the neutral endopeptidase system (ARNI, angiotensin receptor neprilysin inhibitor) is considered a highly significant development in HF therapy.

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